Of 320 buffaloes within 60 days after calving, with the history of reduced feed intake and decreased milk yield presented, 90 (28.13%) buffaloes were found suffering with PPI. On detailed clinical examination and urinalysis, it was observed that 20 (22.22%) buffaloes had hepatic insufficiency with production diseases. Buffaloes, positive for hepatic insufficiency with subclinical hypocalcaemia and hepatic insufficiency with subclinical ketosis were grouped in to group I and II respectively. Urine samples of group I had low calcium, cherry red colour for bile pigments and negative for ketones. While, urine samples of group II revealed normal calcium, cherry red colour for bile pigments and positive for ketones (+ to ++). Serum samples were analysed for glucose, calcium, phosphorus, magnesium, total bilirubin, cholesterol, AST, GGT, total protein and albumin and compared with control buffaloes. Both the groups were administered Rintose @ 0.5g/k g b wt i/v for three days. In addition, group I (n=10) animals were given Tribivet 10 ml i/m for three days and Calup gel 300 g orally for two days, and group II (n=10) animals were given laurabolin 100 mg i/m as single dose and Zigbo boli orally 2 per day for five days. After the therapy, there was significant improvement in serum glucose and calcium levels in both the treatments.
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